In a 2021, Chinese researchers examined the impact of E171 on lipid digestion and vitamin D3 bioaccessibility in a simulated human gastrointestinal tract model. They examined Vitamin D’s bioaccessibility, or the amount it was released in the gastrointestinal tract, becoming available for absorption, and found it “significantly decreased from 80% to 74%” with the addition of E171. In the experiment, E171 decreased lipid digestion dose-dependently. Researchers wrote: “The findings of this study enhance our understanding toward the potential impact of E171 on the nutritional attributes of foods for human digestion health.”  The study was published in the Journal of Agricultural and Food Chemistry, 

Lithopone B301

Faber argued there hasn't been enough change in these federal regulations in the decades following the FDA's approval of titanium dioxide – especially as others increasingly point to potential health consequences.

Animal studies have shown that, when consumed as a food additive, titanium dioxide can induce intestinal inflammation.

How can I tell if a product has titanium dioxide in it? How can I avoid the ingredient?

Rutile Titanium Dioxide MBR9668 Coating Supplier Enhancing Performance and Durability

We even use titanium dioxide when brushing our teeth as it’s found in many toothpastes. 

4. Should I stop eating products that contain TiO₂?

You may be taking a second look at your favorite candy after hearing this week's news about titanium dioxide. Recently, a lawsuit was filed against Mars, Inc. based on claims that the manufacturer's popular Skittles candy is unfit for human consumption. The class-action lawsuit, filed in U.S. District Court for the Northern District of California in mid-July, alleged that the candy contained heightened levels of a known toxin called titanium dioxide — a food additive that the company previously pledged to phase out from their products in 2016, according to the Center for Food Safety.

When sourcing lithopone for leather production, suppliers must ensure they are purchasing a high-quality product from reputable manufacturers. Consistency in particle size and composition is crucial to achieving the desired color intensity and durability in the final leather goods. By partnering with trusted lithopone suppliers, leather manufacturers can guarantee the quality and performance of their products to meet the expectations of consumers.

Micronized titanium dioxide doesn’t penetrate skin so there’s no need to be concerned about it getting into your body. Even when titanium dioxide nanoparticles are used, the molecular size of the substance used to coat the nanoparticles is large enough to prevent them from penetrating beyond the uppermost layers of skin. This means you’re getting the sun protection titanium dioxide provides with no risk of it causing harm to skin or your body. The coating process improves application, enhances sun protection, and prevents the titanium dioxide from interacting with other ingredients in the presence of sunlight, thus enhancing its stability. It not only makes this ingredient much more pleasant to use for sunscreen, but also improves efficacy and eliminates safety concerns. Common examples of ingredients used to coat titanium dioxide are alumina, dimethicone, silica, and trimethoxy capryl silane.

While this ruling from the EU General Court doesn’t immediately change the regulations surrounding titanium dioxide, nor does it change the ban that went into place in 2022, it does put the ingredient back in the spotlight.
 
In the coming months, we will see how the ruling impacts the regulations around titanium dioxide (E171), and we’ll see if the European Food Safety Authority (EFSA) will take another look at the body of scientific evidence used to justify the current ban on E171 in foods and pharmaceuticals.

In a review published in 2022 in the journal Archives of Toxicology, researchers found that the ingestion of E171 is a “a definite health risk for consumers and their progeny.” After reviewing dozens of in vivo, ex vivo and in vitro studies on the toxicity of E171, the researchers wrote that two facts must be noted: “First, reprotoxicity studies show that animals of both sexes are impacted by the toxicity of these nanoparticles, underlining the importance of conducting in vivo studies using both male and female animals. Second, human exposure begins in utero via maternal-fetal transfer and continues after birth by breastfeeding. Children are then chronically re-exposed due to their food preferences. To be relevant to the human in vivo situation, experimental studies should therefore consider nanoparticle exposure with respect to the age or life period of the studied population.”

Report Overview:

Another vital aspect to consider when working with a lithopone pigment pricelist is the effect of quality on pricing. Higher purity pigments generally command a premium price because of their enhanced performance characteristics. When choosing a supplier, it’s essential to look for manufacturers who adhere to strict quality control standards. This ensures that the pigment not only meets industry standards but also performs reliably in various applications, thus justifying any additional costs.

1. Pigment and Food Coloring

Exposure routes are the pathways that allow ingredients to enter our bodies. Primary exposure routes include: 

When asked about the recent Skittles lawsuit, the FDA said the agency does not comment on pending litigation.