Conclusion:
The most significant uncertainty identified by the EU experts was the concern that TiO2 particles may have genotoxic effects. Genotoxicity refers to the ability of a chemical to directly damage genetic material within a cell (DNA), which may lead to cancer in certain situations. Although the experts did not conclude that TiO2 particles in E171 are genotoxic, they could not rule out the concern that they might be.
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≤0.3
As for titanium dioxide, the FDA approved titanium dioxide for use as a food additive in 1966. The last time the agency reviewed the additive’s safety, according to the Guardian, was in 1973.

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