


Was ist HPMC?
Is hydroxypropyl methylcellulose safe in supplements?


Answer: hot water solution method: because HPMC is not dissolved in hot water, so the initial HPMC can be evenly dispersed in hot water, then quickly dissolved when cooling, two typical methods are described as follows:
1) Put the required amount of hot water in the container and heat it to about 70℃. Under the slow stirring gradually add hydroxypropyl methyl cellulose, HPMC began to float on the surface of the water, and then gradually form a slurry, the slurry cooling under the stirring.
2) Add 1/3 or 2/3 of the required amount of water into the container, and heat to 70℃, according to the method of 1), disperse HPMC, prepare hot water slurry; Then add the remaining amount of cold water to the hot slurry, stirring and cooling the mixture.
Powder mixing method: HPMC powder and a large number of other powdery material ingredients, mixing fully with a blender, then add water to dissolve, HPMC at this time can dissolve, and do not stick together, because each small corner, only a little bit of HPMC powder, water will dissolve immediately. - Putty powder and mortar production enterprises are using this method. [Hydroxypropyl methyl cellulose (HPMC) is used as thickening agent and water retaining agent in putty mortar.]

A study published in the Journal of Applied Toxicology evaluated the acute oral toxicity of HPMC in rats and found no side effects at doses up to 5000 mg/kg body weight (the highest dose tested). In addition, subchronic and chronic toxicity studies show no significant side effects in animals, even at high doses.
While HPMC is generally considered safe, some people may experience mild side effects, especially when consumed in high doses. These side effects may include gastrointestinal discomfort, bloating, or diarrhea. However, these effects are usually mild and short-lived and disappear once supplementation is stopped or the dose is reduced.
The mechanism of action of Hydroxypropyl Methylcellulose is a result of its unique molecular structure. HPMC is a cellulose derivative with hydrophilic hydroxypropyl and methyl groups attached to the cellulose backbone. When added to a formulation, HPMC disperses in water to form a colloidal solution.



What is HPMC? (Hydroxypropyl Methylcellulose) | Detailed Explainer

