
HPMC is manufactured following this process:1, 2
The benefits of incorporating HPMC into pharmaceutical formulations are manifold. By utilizing HPMC as a matrix former in sustained-release dosage forms, pharmaceutical manufacturers can achieve precise control over drug release, leading to optimized therapeutic outcomes and minimized side effects. Furthermore, HPMC’s bioadhesive properties make it suitable for use in ophthalmic formulations, enhancing the contact time of drugs with ocular tissues and improving the efficacy of treatments for conditions such as glaucoma and dry eye syndrome. Additionally, HPMC’s compatibility with a variety of active pharmaceutical ingredients and its ability to enhance solubility and bioavailability further contribute to its value in pharmaceutical applications, making it a preferred choice for formulators seeking to develop safe, effective, and patient-friendly drug products.

Answer: HPMC produced through solvent methods uses solvents such as toluene and isopropanol. If the washing process is not thorough, there may be some residual odor.
Answer: HPMC viscosity is inversely proportional to temperature, meaning that viscosity increases as temperature decreases. When we refer to the viscosity of a product, it typically indicates the measurement of its 2% aqueous solution at a temperature of 20 degrees Celsius.
No information on the dusting potential of the additive was made available. The analysis (by sieving) of one batch of the additive8 showed that 100% of the additive had particles smaller than 420 μm.


HPMC is considered a non-fermentable soluble dietary fiber, thus providing several health benefits including reduction of total and low density lipoprotein cholesterol, reducing risk factors of type 2 diabetes and aiding intestinal movements.3