TiO2 NPs appeared to be more toxic to nematode Caenorhabditis elegans than submicron-sized TiO2. At a concentration of 1 mg/l, 7 nm particles affected its fertility and survival rate and were more toxic than 20 nm anatase particles. Similarly, Hu et al. showed that rutile particles (10–20 nm), at concentrations above 1 g/kg soil, can be bio-accumulated in earthworms, where they induce oxidative stress, inhibit the activity of cellulase and induce DNA and mitochondrial damage.
Digestive System Exposure
Titanium dioxide, a versatile and widely used material, finds its application in various industries including the rubber industry
. This white pigment is known for its excellent UV resistance, durability, and opacity, making it an ideal choice for enhancing the properties of rubber products.Titanium dioxide goes into many industrial and consumer products. It makes paper white and bright, it keeps plastics and rubber soft and flexible, and helps remove harmful emissions from car exhaust, among many other uses. In the drug industry, it's a key ingredient in pill capsules and tablet coatings to keep the medicine inside from being affected by sunlight.

Lithopone 30% is a perfect alternative to titanium dioxide in all natural and synthetic pigmented elastomers, as it is non-abrasive and extremely acid resistant.
Still many experts say the body of research does not support the current health concerns being expressed about titanium dioxide.
Promotion of noncancerous tumors
Another important property of Chinese anatase titanium dioxide is its photocatalytic activity, which enables it to break down organic pollutants and harmful chemicals when exposed to light. This makes it an attractive choice for applications in environmental remediation, such as air and water purification systems. Additionally, its photocatalytic properties have also been studied for use in self-cleaning surfaces, such as windows and building facades, where it can help to reduce maintenance costs and keep surfaces looking clean.
chinese anatase titanium dioxide

Most notably, a European Food Safety Authority safety assessment published in May 2021 pointed to genotoxicity concerns, as suggested by previous research. Genotoxicity is the ability of chemicals to damage genetic information such as DNA, which may lead to cancer.

Titanium is a metal element found naturally in the environment. When it's exposed to oxygen in the air, it forms titanium oxides that are contained in many minerals, sands, soils, and dusts.
With a specially designed inorganic surface coating treatment, R-895 excels in weather resistance, making it flexible for use in various indoor and outdoor applications.
It has strong tinting and hiding power, is resistant to alkali and heat, but will decompose when exposed to acid and darken when exposed to light. It has poor weather resistance and is easy to powder, so it is not suitable for outdoor use. In recent years, it has only been used in low-grade products.