The majority of the available studies have been performed in rats, just few of them in rabbits and dogs. Among those meeting the current criteria for toxicological testing, the no observed adverse effect level (NOAEL) values for the different modified celluloses were identified most often corresponding to the highest tested level or changes in body or organ weights. For microcrystalline cellulose (E 460) the identified NOAELs in rats ranged from 3,769 mg/kg body weight (bw) per day to 9,000 mg/kg bw per day and in all cases corresponded to the highest levels of the test substance. For methyl cellulose (E 461), the dose level of 3% in rats (equivalent to 2,700 mg/kw bw per day) was selected as the NOAEL based on a decrease in body and organ weight displayed in male rats administered with the top additive level (10%, equivalent to 9,000 mg/kg bw per day and day).
This is particularly useful for drugs that need to be released slowly over an extended period, such as those used to manage chronic conditions like arthritis or diabetes This is particularly useful for drugs that need to be released slowly over an extended period, such as those used to manage chronic conditions like arthritis or diabetes
Responsible manufacturers adhere to strict environmental guidelines to minimize the ecological footprint of their operations Responsible manufacturers adhere to strict environmental guidelines to minimize the ecological footprint of their operations
Its vegetarian and gluten-free nature makes it a popular choice for health-conscious consumers Its vegetarian and gluten-free nature makes it a popular choice for health-conscious consumers