TiO2 is typically thought of as being chemically inert, meaning it does not react with other chemicals and is, therefore, a stable substance that can be used in many different industries and for various applications.


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It's also worth noting that even prior to the EU decision, France had already outlawed titanium dioxide in food back in January 2020.
In 2021, the European Food Safety Authority concluded that titanium dioxide is no longer safe in foods due to the same concerns over nanoparticles. As a result, titanium dioxide is now banned as a food additive in the EU. Although studies have shown that the absorption of ingested titanium dioxide is low, evidence suggests that titanium dioxide nanoparticles can accumulate in the body over time. Health Canada deemed it safe in 2022 but noted concerns. Unlike their European counterparts, Canadian officials did not consider studies performed with titanium dioxide nanoparticles alone.




Research has shown that, when ingested as a food additive, titanium dioxide and its nanoparticles can impact, alter, and/or damage important protective bacteria in the gut, along with the metabolic pathways of gut bacteria.
In 2017, the Scientific Committee on Consumer Safety (SCCS) warned that they should revise their recommendations if any new evidence emerges in the future related to the potentially harmful effects of TiO2NPs used in a sunscreen formulation or if they can penetrate the skin. In fact, our work could contribute to this matter because it evaluated the skin penetration of a particular kind of TiO2NPs. [8]