No analytical data that would support the identification of the active substance and the batch to batch consistency of the additive was provided.
HPMC is especially valued for its role as a capsule shell. Traditional gelatin capsules are made from animal by-products, making them unsuitable for vegetarians and vegans. HPMC capsules, on the other hand, are completely plant-based and offer an excellent alternative that suits a wide range of dietary preferences.
- Redispersible polymer powders have emerged as a vital ingredient in various industries, particularly in construction, due to their unique properties that enhance product performance and durability. These powders, when mixed with water, regain their original colloidal state, making them indispensable for applications such as tile adhesives, mortar formulations, and coating technologies. The global market for redispersible polymer powders is supported by a network of dedicated suppliers who ensure consistent quality and reliability.
- 2. Energy Efficiency The factory uses energy-efficient equipment and technologies to reduce its energy consumption.
HPMC
19.What is the difference between HPMC and MC?

What is HPMC used for?
It is most frequently utilized in vegan-friendly products as a gelatin and gluten substitute. HPMC can be used as toothpaste, mouthwash, and other oral care products and cosmetics. It acts as a moisturizer on the skin, but it's not approved to be used in that capacity by the FDA. HPMC is used in medicine to help prevent or treat diarrhea caused by certain antibiotics or other medications. It can also be used as an ointment for wounds or burns because it provides relief from pain and healing without leaving behind any scarring or discoloration.
HPMC gel can be incorporated into wound dressings and bandages to provide a moist environment for wound healing. Its biocompatibility and non-toxicity make it suitable for medical applications.
2. HPMC produced
There are data for microcrystalline cellulose (E 460), methyl cellulose (E 461), hydroxypropyl cellulose (E 463) and sodium carboxymethyl cellulose (E 466), which were tested in mice, rats, hamsters and/or rabbits with oral dosing or via gavage. As regards microcrystalline cellulose (E 460) studies have been conducted in rats (dietary exposure) with a mixture including guar gum or sodium carboxymethylcellulose (E 466) (15% in either case). The NOAEL for both maternal and developmental toxicity were the highest experimental dosages, i.e. 4,500 mg/kg bw (for mixture with guar gum) and 4,600 mg/kg bw (for mixture with sodium carboxymethyl cellulose). Methyl cellulose (E 461) was examined in mice, rats, hamsters and rabbits. In two different studies, pregnant mice were exposed via gavage (vehicle corn oil) to a dose range of 16-1,600 mg methyl cellulose (E 461)/kg bw per day from day 6 to 15 of gestation, followed by a caesarean section at day 17 of gestation. In the first study, maternal toxicity (increase in mortality and reduced pregnancy rate in the survivors) as well as retarded ossification in fetuses were noticed at the highest tested level, pointing to a NOAEL of 345 mg methyl cellulose (E 461) mg/kg bw per day (the last but one highest dosage) in mice. In the second study, no maternal toxicity and fetal abnormalities were observed in mice exposed up to 700 mg methyl cellulose (E 461) mg/kg bw per day. Rat studies (n = 2) were performed in pregnant dams exposed via gavage (vehicle corn oil) to a dose range of 16-1,320 mg methyl cellulose (E 461) mg/kg bw per day from day 6 to 15 of gestation followed by a caesarean section at day 20. In the first study (0, 13, 51, 285 or 1,320 mg methyl cellulose (E 461)/kg bw per day) the highest tested dosage resulted in no maternal toxicity but also in increased incidence of extra centres of ossification in vertebrae of fetuses from high dose dams; in a second rat study, the incidence of such alteration slightly increased in fetuses from the highest dosed group (1,200 mg methyl cellulose (E 461)/kg bw per day). Based on the above results, a NOAEL of 285 mg methyl cellulose (E 461) mg/kg bw per day could be identified in rats. No maternal or fetal toxicity was detected in Golden hamsters exposed via gavage (vehicle corn oil) up to 1,000 mg methyl cellulose (E 461) mg/kg bw per day from day 6 to 10 of gestation followed by a caesarean section at day 20. The study on rabbits was discarded due to poor experimental design. The only relevant developmental toxicity study with hydroxypropyl cellulose (E 463) (dissolved in 1% gum arabic solution) was performed in pregnant rats exposed via gavage from day 7 to 17 of gestation to 0, 200, 1,000 or 5,000 mg/kg bw test item and some of them subjected to caesarean sections at day 20. No treatment-related adverse effects were detected in dams or in the examined fetuses. A number of dams were allowed to deliver and no clinical, behavioural or morphological changes were observed in the examined pups. Their reproductive ability was seemingly not affected and no abnormalities were found in the F1-derived fetuses. The in utero exposure to the highest dose (5,000 mg/kg bw per day) may be considered as the NOAEL of methyl cellulose (E 461) for this study. No mortality, and no adverse effects were observed on implantation or on fetal survival in pregnant mice or rats dosed via gavage with up to 1,600 mg sodium carboxymethyl cellulose (E 466)/kg bw per day.


You may report side effects to your national health agency.

Declaration of ingredients on the label
In supplements, HPMC is often combined with other ingredients such as vitamins, minerals, plant extracts, and amino acids. While HPMC itself is unlikely to interact with these ingredients, potential interactions between other components of the supplement must be considered. For example, certain vitamins or minerals may interact with medications or other supplements, causing adverse reactions or reduced effectiveness.

