Titanium dioxide has similar uses in non-food products. It is used in sunscreen as effective protection against UVA/UVB rays from the sun, which creates a physical barrier between the sun’s rays and the skin. It’s also used to whiten paint, paper, plastic, ink, rubber, and cosmetics.

Calcium carbonate (CaCO3) and titanium dioxide (TiO2) are two widely used industrial materials with various applications. In this article, we will discuss the importance of CaCO3 and TiO2 in manufacturing processes and their impact on the global economy.
A few non-dietary studies have reported adverse effects in the gastrointestinal tract of laboratory animals given food-grade TiO2. However, these same effects were not seen when the same or higher doses of food-grade TiO2 were administered in the animals' diet. Dietary studies best reflect how humans are exposed to TiO2 from food. Thus, the Food Directorate placed the most emphasis on the results of these studies in the state of the science report.
105°C volatile matter, %
Animal studies have shown that, when consumed as a food additive, titanium dioxide can induce intestinal inflammation.
≤0.3
As a widely used substance with multiple applications, research is being carried out to improve the production process to reduce the levels of chemicals used and waste produced, and to recycle any by-products.
In general, nanoparticles have been shown to accumulate in the body, particularly in organs in the gastrointestinal tract, along with the liver, spleen, and capillaries of the lungs.
Following the EU’s ban on E171, the FDA told the Guardian that, based on current evidence, titanium dioxide as a food additive is safe. “The available safety studies do not demonstrate safety concerns connected to the use of titanium dioxide as a color additive.”
Lithopone is produced by coprecipitation of barium sulfate and zinc sulfide. Most commonly coprecipitation is effected by combining equimolar amounts of zinc sulfate and barium sulfide:
Toxic effects of TiO2 NPs on soil organisms
The committee could not finalize the assessment of some other flavoring agents, requiring further information. JECFA highlighted the importance of receiving complete data submissions from the sponsors for conducting the safety evaluation.
≥99.0
What is the FDA limit for titanium dioxide?
The National Cancer Institute tested TiO2 for possible carcinogenicity by the oral route of exposure by feeding rats and mice with TiO2 (size not specified) at doses 25,000 or 50,000 ppm TiO2 for 103 weeks. They concluded that TiO2 was not carcinogenic.Also, the study with rats fed diets containing up to 5 % TiO2 coated mica for 130 weeks showed no treatment-related carcinogenicity. Since the size and other TiO2 properties were not specified or determined, we cannot generalize this conclusion and we have to take into account other possible outcomes of this scenario in different exposure conditions (other size/crystalline structure of TiO2 etc.).