3. Easy Maintenance Flat belts are straightforward to maintain and replace, which reduces downtime.



This article was written by Kamilah Guiden and reviewed by Megan Meyer, PhD.
While this ruling from the EU General Court doesn’t immediately change the regulations surrounding titanium dioxide, nor does it change the ban that went into place in 2022, it does put the ingredient back in the spotlight.
In the coming months, we will see how the ruling impacts the regulations around titanium dioxide (E171), and we’ll see if the European Food Safety Authority (EFSA) will take another look at the body of scientific evidence used to justify the current ban on E171 in foods and pharmaceuticals.
lithopone supplier 30% complies with both the REACH and Indirect Food Regulations, as well as with many European regulations regarding Toys, Packaging, Resins, etc…
In a 2017 study published in Scientific Reports, researchers exposed rats to human-relevant levels of E171 to examine the effects of intestinal inflammation and carcinogenesis. They saw that “a 100-day E171 treatment promoted colon microinflammation and initiated preneoplastic lesions while also fostering the growth of aberrant crypt foci in a chemically induced carcinogenesis model.” They continued: “Stimulation of immune cells isolated from Peyer’s Patches [which are clusters of lymphoid follicles found in the intestine] showed a decrease in Thelper (Th)-1 IFN-γ secretion, while splenic Th1/Th17 inflammatory responses sharply increased,” researchers wrote. “A 100-day titanium dioxide treatment promoted colon microinflammation and initiated preneoplastic lesions.” The scientists concluded: “These data should be considered for risk assessments of the susceptibility to Th17-driven autoimmune diseases and to colorectal cancer in humans exposed to TiO2 from dietary sources.”
R-895 is a paint grade titanium dioxide pigment produced by the chlorination process. Recommended for use in a variety of coating applications.
On the other hand, the U.S. Food and Drug Administration (FDA) in their Final Administrative Order on Sunscreen Drug Products posted in September 2021 still accepts titanium dioxide up to 25% in the list of Generally Recognized As Safe and Effective (GRASE) in the main document, without further clarification on what kind or size of particles [9]. However, on page 24 (Sunscreen containing nanomaterials) FDA clearly “distinguish nanomaterials from other forms of these ingredients'' (zinc oxide and titanium dioxide) and ask for comments on “any particular nanomaterials that you believe should not be permitted for use in OTC sunscreen products”. To the best of our knowledge, this Agency did not ban the use of nanoparticulate titanium dioxide in any form, even though it is mentioned on page 34 that the anatase form is the more photoactive one, due to the lack of evidence with real sunscreens OTC (over the counter) in vivo. Moreover, other regulations in Latin America (MERCOSUR agreement, 2006) do not state clearly their position on the use of nanoparticulate TiO2NPs [10].
Assessment of biocompatibility in prokaryotic cells
The most common foods containing titanium dioxide are chewing gum, candies, pastries, chocolates, coffee creamers, and cake decorations (1Trusted Source, 3Trusted Source).


Application of lithopone in rubber and plastics application of lithopone in plastics and pigments lithopone can whiten and improve the compressive strength of products. Lithopone is easy to disperse rapidly, and thus the production process of this product is convenient, especially the molding, injection molding and actual operation process. It is worth mentioning that, with its organic chemical plasticity, it can also be integrated into the vulcanized rubber effect of recycled rubber.
The price trendss for titanium dioxide kept on the lower side of the scale during the first half of 2023. As the paint and coatings industries reduced their offtakes, the abundant supply of the product in the market led to a fall in prices. The prices also suffered from falling energy costs and declining freight charges. Further, the rising speculations of a global recession caused manufacturers to participate actively in destocking.
Most notably, a European Food Safety Authority safety assessment published in May 2021 pointed to genotoxicity concerns, as suggested by previous research. Genotoxicity is the ability of chemicals to damage genetic information such as DNA, which may lead to cancer.
Titanium dioxide remains in many food products in this country because of regulatory folly by the Food and Drug Administration, which allows problematic food ingredients to remain undetected and unreviewed.
Nano-sized TiO2 generally shows low or no acute toxicity in both invertebrates and vertebrates. However, exposure of Daphnia magna to 20 ppm TiO2 for 8 consecutive days was found to cause 40 % mortality. Zhu et al. showed minimal toxicity to D. magna after 48 h exposure, while upon chronic exposure for 21 days, D. magna suffered severe growth retardation and mortality. A significant amount of nano-sized TiO2 was found also accumulated in the body of the animals. Similar findings with coated nano-sized TiO2 (T-Lite™ SF, T-Lite™ SF-S and T-Lite™ MAX; BASF SE) were reported by Wiench et al. Biochemical measurements showed that exposure to TiO2 NPs induces significant concentration-dependent antioxidant enzyme activities in D. magna. Lee et al. showed that 7 and 20 nm-sized TiO2 induced no genotoxic effect in D. magna and in the larva of the aquatic midge Chironomus riparius.